Literature summary for 3.4.24.B4 extracted from

Hong, H.; Park, Y.K.; Choi, M.S.; Ryu, N.H.; Song, D.K.; Suh, S.I.; Nam, K.Y.; Park, G.Y.; Jang, B.C.
Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride (2009), J. Dermatol. Sci., 56, 43-50.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin fibroblast	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	glucosamine-hydrochloride differentially downregulates COX-2 andMMP-13 expression in the interleukin-1beta-treated or phorpbol-12-myristate-13-acetate-treated skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively	down
Homo sapiens	interleukin-1beta treatment induces COX-2 and MMP-13 expressions in association with activation of ERKs, p38 MAPK, JNKs, and NF-kappaB in skin fibroblasts. Phorbol-12-myristate-13-acetate treatment also induces COX-2 and MMP-13 expressions in association with p38 MAPK activation	up

General Information

General Information	Comment	Organism
metabolism	interleukin-1beta treatment induces COX-2 and MMP-13 expressions in association with activation of ERKs, p38 MAPK, JNKs, and NF-kappaB in skin fibroblasts. Phorbol-12-myristate-13-acetate treatment also induces COX-2 and MMP-13 expressions in association with p38 MAPK activation. Glucosamine-hydrochloride differentially downregulates COX-2 andMMP-13 expression in the interleukin-1beta- or phorpbol-12-myristate-13-acetate-treated skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively	Homo sapiens

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Release 2023.1 (January 2023)