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Literature summary for 3.4.24.B4 extracted from

  • Yang, C.M.; Hsieh, H.L.; Yao, C.C.; Hsiao, L.D.; Tseng, C.P.; Wu, C.B.
    Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells (2009), J. Biol. Chem., 284, 26040-26050.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors Comment Organism Structure
AG1296 a platelet-derived growth factor receptor inhibitor, shows several physiological effects, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Mus musculus 31012
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus
Zn2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Mus musculus
-
 ?
-
 ?
additional information Mus musculus MMP-13 degrades intact collagen and participates in situations where rapid and effective remodeling of collagenous extracellular matrix is required ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MC3T3-E1 cell
-
 Mus musculus
-
osteoblast primary Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Mus musculus ?
-
 ?
additional information MMP-13 degrades intact collagen and participates in situations where rapid and effective remodeling of collagenous extracellular matrix is required Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
collagenase 3
-
 Mus musculus
MMP-13
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus mechanical strain induction of MMP-13 by high mechanical forces, with receptor of platelet-derived growth factor receptor alpha, PDGFR-alpha, as a potential mechanoreceptor in the MMP-13 induction, inhibited by platelet-derived growth factor receptor inhibitor AG1296, overview. The receptor performs autophosphorylation under mechanical stress up

General Information

General Information Comment Organism
physiological function MMP-13 participate in the bone-remodeling mechanism involving the platelet-derived growth factor receptor Mus musculus