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Literature summary for 3.4.24.B4 extracted from

  • Kumamoto, K.; Fujita, K.; Kurotani, R.; Saito, M.; Unoki, M.; Hagiwara, N.; Shiga, H.; Bowman, E.D.; Yanaihara, N.; Okamura, S.; Nagashima, M.; Miyamoto, K.; Takenoshita, S.; Yokota, J.; Harris, C.C.
    ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression (2009), Int. J. Cancer, 125, 1306-1315.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
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Homo sapiens
-
colorectal cancer cell
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Homo sapiens
-
HCT-116 cell
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Homo sapiens
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LS-174T cell
-
Homo sapiens
-
SW-620 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase 13
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Homo sapiens
MMP13
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens inhibitor of growth 2, ING2, upregulates expression of MMP13, which enhances cancer invasion and metastasis. MMP13 expression is further enhanced by combination of the synergistically acting ING2 and HDAC1 up

General Information

General Information Comment Organism
additional information the ING2-HDAC1-mSin3A complex members regulates expression of MMP13. Upregulation of ING2 is associated with colon cancer and MMP13-dependent cellular invasion Homo sapiens