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Literature summary for 3.4.24.B4 extracted from

  • Lecomte, J.; Louis, K.; Detry, B.; Blacher, S.; Lambert, V.; Bekaert, S.; Munaut, C.; Paupert, J.; Blaise, P.; Foidart, J.M.; Rakic, J.M.; Krane, S.M.; Noel, A.
    Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization (2011), Cell. Mol. Life Sci., 68, 677-686.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Organism

Organism UniProt Comment Textmining
Homo sapiens P45452 gene Mmp13
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Mus musculus
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 gene Mmp13
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Mus musculus C57BL/6
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 gene Mmp13
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
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 Mus musculus
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bone marrow
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 Homo sapiens
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additional information Mmp13 is expressed in human neovascular membranes Homo sapiens
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additional information Mmp13 is expressed in mouse choroidal neovascular lesions induced by laser burn Mus musculus
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Synonyms

Synonyms Comment Organism
collagenase-3
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 Mus musculus
collagenase-3
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 Homo sapiens
MMP13 a matrix metalloproteinase family member Mus musculus
MMP13 a matrix metalloproteinase family member Homo sapiens

General Information

General Information Comment Organism
additional information MMP13 involvement in age-related macular degeneration Homo sapiens
additional information potential role of MMP13 in choroidal angiogenesis in a murine model of laser-induced ocular neovascularisation. Deficiency of Mmp13 impaires choroidal neovascularization formation which is fully restored by wild-type bone marrow engraftment and partially rescued by several injections of wild-type mesenchymal stem cells. Mmp13 deficiency not only affects vessel recruitment, but also impairs their maturation through pericyte coverage Mus musculus