Literature summary for 3.4.24.B4 extracted from

Tan, T.W.; Yang, W.H.; Lin, Y.T.; Hsu, S.F.; Li, T.M.; Kao, S.T.; Chen, W.C.; Fong, Y.C.; Tang, C.H.
Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells (2009), Carcinogenesis, 30, 258-268.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrosarcoma cell	-	Homo sapiens	-
JJ012 cell	a chondrosarcoma cell line	Homo sapiens	-
SW-1353 cell	a chondrosarcoma cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	Cyr61 increases the binding of c-Fos and c-Jun to the activator protein-1 element on the MMP-13 promoter, and Cyr61 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphanybeta3 integrin receptor, FAK, ERK, c-Fos/c-Jun and activator protein-1 signal transduction pathway. The upregulation of MMP-13 is antagonized by decoy agonist AP-1-binding site, AP-1 oligonucleotide, but not by NF-kappaB oligonucleotide or scrambled oligonucleotide, as well as by RGD, PD98059 and FAK(Y397F) and ERK2 mutant. Pretreatment with RGD and PD98059 or transfection with FAK and ERK2 mutant of JJ012 cells inhibits the Cyr61-induced increase in AP-1 promoter activity	up

General Information

General Information	Comment	Organism
additional information	MMP-13 transcriptional regulation, overview	Homo sapiens
physiological function	involvement of MMP-13 and upregulation in the Cyr61-directed chondrosarcoma cells migration, the upregulation of MMP-13 is antagonized by decoy agonist AP-1-binding site, AP-1 oligonucleotide, but not by NF-kappaB oligonucleotide or scrambled oligonucleotide, as well as by RGD, PD98059 and FAK(Y397F) and ERK2 mutant	Homo sapiens

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Release 2023.1 (January 2023)