Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B4 extracted from

  • Cheng, C.; Tempel, D.; van Haperen, R.; van Damme, L.; Alguer, M.; Krams, R.; de Crom, R.
    Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype (2009), Atherosclerosis, 204, 26-33.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Mus musculus 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen type I + H2O Mus musculus Interstitial fibers of collagen type I in the plaque can be degraded by MMP13 specifically. MMP13 is capable of degrading collagen type I in the upstream atherosclerotic lesions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mice deficient in apolipopotein E (apoE -/-) in a C57BL/6J background
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
 Mus musculus
-
chondrocyte articular Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Mus musculus ?
-
 ?
Collagen type I + H2O Interstitial fibers of collagen type I in the plaque can be degraded by MMP13 specifically. MMP13 is capable of degrading collagen type I in the upstream atherosclerotic lesions Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP13
-
 Mus musculus

General Information

General Information Comment Organism
additional information angiotensin II promotes a stable fibrotic phenotype by inducing severe intra-plaque hemorrhages, characterized by increased degradation of interstitial collagen I via an MMP13 or MMP8-mediated mechanism, overview Mus musculus