Cloned (Comment) | Organism |
---|---|
MMP-13 real-time PCR expression analysis, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of MMP-13 by stable retrotransduction of short hairpin RNA leads to impaired ECM remodeling and suppressed differentiation in conjunction with reduced levels of RUNX-2, beta-catenin, and vascular endothelial growth factor, VEGF | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Homo sapiens | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
type II collagen + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
chondrocyte | primary, MMP-13 real-time PCR expression analysis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
type II collagen + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase 13 | - |
Homo sapiens |
MMP-13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | MMP-13 levels in vitro and extracellular matrix remodeling in vitro and in vivo are linked to changes in SOX9 subcellular localization, loss of MMP-13 or IKKalpha leads to the nuclear localization of SOX9. IKKalpha ablation in articular chondrocytes stabilizes their extracellular matrix by posttranscriptionally suppressing MMP-13 activity, thereby blocking their differentiation and maintaining them in an early periarticular-like state | Homo sapiens |
physiological function | MMP-13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors. MMP-13 loss alone impedes the differentiation of primary chondrocyte micromasses by inhibiting the expression or activation of multiple regulatory factors including runt-related transcription factor 2, RUNX-2, vascular endothelial growth factor, VEGF, and beta-catenin, and enhances chondrocyte viability. The inhibitory effects of MMP-13 ablation on several principal regulators of chondrocyte maturation toward a hypertrophic-like state occurr in conjunction with diminished type X collagen expression | Homo sapiens |