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Literature summary for 3.4.24.B4 extracted from

  • Choi, H.M.; Lee, Y.A.; Lee, S.H.; Hong, S.J.; Hahm, D.H.; Choi, S.Y.; Yang, H.I.; Yoo, M.C.; Kim, K.S.
    Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators (2009), Arthritis Res. Ther., 11, R161.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
fibroblast-like synoviocyte from rheumatoid arthritis patients Homo sapiens
-
rheumatoid arthritis disease specific synovial fluid from healthy persons and rheumatoid arthritis patients, the latter show a higher MMP-13 level Homo sapiens
-
synovial fluid from healthy persons and rheumatoid arthritis patients, the latter show a higher MMP-13 level Homo sapiens
-

Synonyms

Synonyms Comment Organism
MMP-13
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens adiponectin and interleukin-1beta induce MMP-13 expression and secretion in cell cultures, adiponectin plays a role in the pathogenesis of arthritis as a proinflammatory mediator up