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Literature summary for 3.4.24.B4 extracted from

  • Hattori, N.; Mochizuki, S.; Kishi, K.; Nakajima, T.; Takaishi, H.; DArmiento, J.; Okada, Y.
    MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing (2009), Am. J. Pathol., 175, 533-546.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
reverse transcription-PCR expression analysis of MMP13 in wild-type and mutant mice, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of MMP13 and MMP13/MMP9 knockout mice, that all show delayed wound closure compared to wild-type mice. The rate of re-epithelialization is significantly delayed in MMP-9 KO and MMP-13 KO mice and remarkably delayed in MMP-9/13 double KO mice, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
BB94 a broadspectrum MMP inhibitor, significantly inhibits keratinocyte migration Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
Mus musculus 31012
-

Organism

Organism UniProt Comment Textmining
Mus musculus
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129/Sv and C57BL/6J mice
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Source Tissue

Source Tissue Comment Organism Textmining
additional information expression analysis of MMP13 in healthy and wounded skin, overview Mus musculus
-
skin MMP-13 expression is negligible in the normal unwounded skin at day 0, but it increases on days 1 to 7 upon wounding, diminishes on day 14 and disappears on day 28 Mus musculus
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Synonyms

Synonyms Comment Organism
MMP-13
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus keratinocytes transfected with siRNA for MMP-13 exhibit downregulation of mRNA and protein expression of the MMP down
Mus musculus MMP13 expression is transiently induced by wounding, MMP-13 expression is negligible in the normal unwounded skin at day 0, but it increases on days 1 to 7 upon wounding, diminishes on day 14 and disappears on day 28 up

General Information

General Information Comment Organism
physiological function MMP13 affects the keratinocyte migration in the skin, overview. Connective tissue growth factor, CTGF, blocks angiogenic activity of vascular epithelial growth factor, VEGF, by complex formation, and MMP13 re-activates VEGF activity through selective cleavage of CTGF in the complex Mus musculus