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Literature summary for 3.4.24.B4 extracted from

  • Wu, J.; Rush, T.S.; Hotchandani, R.; Du, X.; Geck, M.; Collins, E.; Xu, Z.B.; Skotnicki, J.; Levin, J.I.; Lovering, F.E.
    Identification of potent and selective MMP-13 inhibitors (2005), Bioorg. Med. Chem. Lett., 15, 4105-4109.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors Comment Organism Structure
N-([4'-[(1-benzofuran-2-ylcarbonyl)amino]biphenyl-4-yl]sulfonyl)valine 50% inhibition at 1.3 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-([4'-[([5-[(methylsulfonyl)amino]-1-benzofuran-2-yl]carbonyl)amino]biphenyl-4-yl]sulfonyl)valine 50% inhibition at 0.43 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[(4'-[[(4-methoxy-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]valine 50% inhibition at 2.33 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[(4'-[[(5-amino-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]valine 50% inhibition at 1.5 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[(4'-[[(5-chloro-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]valine 50% inhibition at 0.6 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[(4'-[[(5-methoxy-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]valine 50% inhibition at 0.66 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[(4'-[[(5-nitro-1-benzofuran-2-yl)carbonyl]amino]biphenyl-4-yl)sulfonyl]valine 50% inhibition at 0.7 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus
N-[[4'-([[5-(acetylamino)-1-benzofuran-2-yl]carbonyl]amino)biphenyl-4-yl]sulfonyl]valine 50% inhibition at 0.98 nM, comparison with inhibition of matrix metalloproteinases MMP-2, MMP-14 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
cartilage articular cartilage explant model Bos taurus
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