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Literature summary for 3.4.24.B3 extracted from

  • Barrasa, J.I.; Olmo, N.; Santiago-Gomez, A.; Lecona, E.; Anglard, P.; Turnay, J.; Lizarbe, M.A.
    Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells (2012), Biochim. Biophys. Acta, 1823, 570-581.
    View publication on PubMed
Search for more literature for 3.4.24.B3

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 x * 44000, active processed form, SDS-PAGE Homo sapiens
55000
-
 x * 55000, proenzyme form, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BCS-TC2 cell
-
 Homo sapiens
-
Caco-2 cell
-
 Homo sapiens
-
colonic adenocarcinoma cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 44000, active processed form, SDS-PAGE Homo sapiens
? x * 55000, proenzyme form, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MMP-11
-
 Homo sapiens
stromelysin-3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens treatment of BCS-TC2 cells with butyrate and trichostatin A (histone deacetylase inhibitors) increases MMP11 promoter activity 1.5-2fold and protein expression 1.4-1.7fold. Sp1 is involved in MMP11 basal expression and is essential for the upregulation of transcription by histone deacetylase inhibitors. ERK1/2-mitogen-activated protein kinase, but not p38-MAPK or JNK, is involved in the upregulation of MMP11 by histone deacetylase inhibitors up