Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
exosome | - |
Homo sapiens | - |
- |
extracellular | - |
Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13444 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | exosomes rich in ADAM15 display enhanced binding affinity for integrin alpha/beta3 in an Arg-Gly-Asp-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. Exosomal ADAM15 is released from human macrophages, and macrophage-derived ADAM15 exosomes have tumor inhibitory effects | Homo sapiens |