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Literature summary for 3.4.24.B20 extracted from
- Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of lambdaCII in vitro (2010), Arch. Biochem. Biophys., 501, 239-243.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | - |
Escherichia coli |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| HflC protein | purified recombinant His6-tagged, 74 kDa dimers from Escherichia coli expressed in strain Bl21, inhibits the proteolysis of lambdaCII by FtsH, i.e. HflB, both in vitro and in vivo, mechanism, overview. Each HflC molecules interacts with another HflC molecule attached to the juxtaposed HflB | Escherichia coli | |
| HflK protein | purified recombinant His6-tagged, 74 kDa dimers from Escherichia coli expressed in strain Bl21, inhibits the proteolysis of lambdaCII by FtsH, i.e. HflB, both in vitro and in vivo, mechanism, overview. Each HflK molecules interacts with another HflK molecule attached to the juxtaposed HflB | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli | |
| Zn2+ | required | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lambdaCII + H2O | Escherichia coli | the key protein that influences the lysis/lysogeny decision of lambda by activating several phage promoters | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lambdaCII + H2O | - |
Escherichia coli | ? | - |
? | |
| lambdaCII + H2O | the key protein that influences the lysis/lysogeny decision of lambda by activating several phage promoters | Escherichia coli | ? | - |
? | |
| sigma32 + H2O | substrate from Escherichia coli | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FtsH | - |
Escherichia coli |
| HflB | - |
Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Escherichia coli |
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