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Literature summary for 3.4.24.B18 extracted from

  • Leonhard, K.; Herrmann, J.M.; Stuart, R.A.; Mannhaupt, G.; Neupert, W.; Langer, T.
    AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria (1996), EMBO J., 15, 4218-4229.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B18

Protein Variants

Protein Variants Comment Organism
E614Q site-directed mutagenesis, exchange of active site residue, stongly reduced activity Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane inner side, exposes catalytic sites to the mitochondrial matrix Saccharomyces cerevisiae 5743
-
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Saccharomyces cerevisiae
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 in complex with Yme1p, EC 3.4.24.B19, forming i-AAA protease
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins conserved metal-binding site HEXXH, selective degradation, mechanism Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hybrid protein + H2O hybrid protein of subunit 2 of cytochrome oxidase residues 1-74, mouse dihydrofolate reductase, and mitochondrial presequence, residues 1-66, of subunit 9 of the ATPase of Neurospora crassa, in vitro import into the mitochondrion Saccharomyces cerevisiae 2 peptide fragments f2 and f3 product characterization ?
additional information Yta12p enzyme requires YTA10-12 complex formation for activity Saccharomyces cerevisiae ?
-
 ?
protein + H2O
-
 Saccharomyces cerevisiae peptides
-
 ?
residues 1-74 of subunit 2 of cytochrome oxidase + H2O two-step procedure, in vitro import into the mitochondrion Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
M41.003 Merops-ID Saccharomyces cerevisiae
YTA12p
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Saccharomyces cerevisiae