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Literature summary for 3.4.24.B17 extracted from

  • Kihara, A.; Akiyama, Y.; Ito, K.
    FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit (1995), Proc. Natl. Acad. Sci. USA, 92, 4532-4536.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B17

Cloned(Commentary)

Cloned (Comment) Organism
expression of several mutant enzyme forms Escherichia coli

Protein Variants

Protein Variants Comment Organism
L189W mutation ftsH102, partial complementation of temperature sensitivity of the ftsH1 mutant at 42°C but not other cols-sensitive mutants, overview Escherichia coli
additional information defects in the ftsH gene stabilize the SecY protein, overexpression increase the degradation of SecY, enzyme deficient mutantion ftsH101 suppresses the temperature-sensitive export defect of a secY24 mutant G240D in the cytoplasmic domain of SecY by stabilizing the mutant protein Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
protein SecE stabilizes overexpressed SecY against proteolytic degradation by the enzyme, acts a an antagonist Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Escherichia coli
-
 peptides
-
 ?
protein SecY + H2O Escherichia coli quality control, the enzyme regulates the amount of SecY assembled in the mitochondrial membrane, elimination of uncomplexed SecY is important for optimum protein translocation and for the integrity of the membrane ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein + H2O
-
 Escherichia coli peptides
-
 ?
protein SecY + H2O
-
 Escherichia coli ?
-
 ?
protein SecY + H2O quality control, the enzyme regulates the amount of SecY assembled in the mitochondrial membrane, elimination of uncomplexed SecY is important for optimum protein translocation and for the integrity of the membrane Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
M41.001 Merops-ID Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Escherichia coli