Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphoramidon | - |
Homo sapiens | |
phosphoramidon | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Mus musculus | |
thiorphan | - |
Homo sapiens | |
thiorphan | the inhibitor induces a dramatic increase in amyloid-beta peptide levels | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | human neprilysin-2-beta is either localized to the extracellular surface or secreted | Homo sapiens | 9986 | - |
extracellular | due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta) | Mus musculus | - |
- |
extracellular | human neprilysin-2-beta is either localized to the extracellular surface or secreted | Homo sapiens | - |
- |
membrane | due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta) | Mus musculus | 16020 | - |
additional information | alternative splicing acts on the human form of neprilysin-2 creating several isoforms. Isoform hNEP2-gamma does not show secreted amyloid beta peptide-degrading activity or activity at the cell surface | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
gonadotropin-releasing hormone + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Mus musculus | in vivo in cells membrane-bound isoforms mNEP2-alpha and mNEP2-beta have similar activity against amyloid beta peptide Ab40 and Ab42 compared to neprilysin, EC 3.4.24.11 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q495T6 | - |
- |
Mus musculus | Q9JLI3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | peripheral | Homo sapiens | - |
brain | while NEP2 is expressed at variable levels in most brain regions, it is most highly expressed in the brain stem, hypothalamus and pituitary | Mus musculus | - |
brain | while NEP2 is expressed at variable levels in most brain regions. Levels of neprilysin-2 mRNA in those with Alzheimer's disease are not different from non-impaired controls | Homo sapiens | - |
brain stem | high enzyme level | Mus musculus | - |
hypothalamus | high enzyme level | Mus musculus | - |
pituitary gland | high enzyme level | Mus musculus | - |
testis | - |
Mus musculus | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
gonadotropin-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | in vivo in cells membrane-bound isoforms mNEP2-alpha and mNEP2-beta have similar activity against amyloid beta peptide Ab40 and Ab42 compared to neprilysin, EC 3.4.24.11 | Mus musculus | ? | - |
? | |
additional information | human neprilysin-2 has a more restricted substrate specificity compared to human neprilysin, EC 3.4.24.11, with less activity against several vasoactive peptides | Homo sapiens | ? | - |
? | |
additional information | in vitro membrane-bound isoform mNEP2-alpha has slower and weaker amyloid beta peptide Ab40 degrading properties when compared to neprilysin, EC 3.4.24.11, and shows little to no effect on amyloid beta peptide Ab42. Membrane-bound isozymes mNEP2-beta and gamma have nearly undetectable activity against amyloid beta peptide | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane-bound metalloendopeptidase-like enzyme 1 | - |
Homo sapiens |
membrane-bound metalloendopeptidase-like enzyme 2 | - |
Homo sapiens |
MMEL1 | - |
Homo sapiens |
MMEL2 | - |
Homo sapiens |
NEP-like endopeptidase | - |
Mus musculus |
NEP-like endopeptidase | - |
Homo sapiens |
NEP2 | - |
Mus musculus |
NEP2 | - |
Homo sapiens |
NEPLP | - |
Mus musculus |
neprilysin-2 | - |
Mus musculus |
neprilysin-2 | - |
Homo sapiens |
neprilysin-like protein | - |
Mus musculus |
Nl1 | - |
Mus musculus |
SEP | - |
Mus musculus |
soluble-secreted endopeptidase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the altered enzyme expression has a sexually dimorphic change, with mild-cognitive impaired males having significantly elevated NEP2 mRNA levels compared to non-impaired males in the mid-temporal and mid-frontal gyri | additional information |
General Information | Comment | Organism |
---|---|---|
evolution | neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin | Mus musculus |
evolution | neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin | Homo sapiens |
malfunction | NEP2 knockout mice show reduced sperm function | Mus musculus |
malfunction | reduced enzyme activity in association with mild-cognitive impaired subjects and Alzheimer's disease subjects regardless of sex | Homo sapiens |
metabolism | neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain | Mus musculus |
metabolism | neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain | Homo sapiens |
additional information | enzyme splice variants and their involvement in amloid beta peptide cleavage, overview | Mus musculus |
additional information | enzyme splice variants and their involvement in amyloid beta peptide cleavage, overview | Homo sapiens |
physiological function | NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. Neprilysin-2 has importance in amyloid peptide regulation | Mus musculus |
physiological function | NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. The enzyme might play a role in the metabolism of neuropeptides of the hypothalamo-pituitary axis | Homo sapiens |