Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B14 extracted from

  • Marr, R.A.; Hafez, D.M.
    Amyloid-beta and Alzheimers disease: the role of neprilysin-2 in amyloid-beta clearance (2014), Front. Aging Neurosci., 6, 187.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
Homo sapiens
phosphoramidon the inhibitor induces a dramatic increase in amyloid-beta peptide levels Mus musculus
thiorphan
-
Homo sapiens
thiorphan the inhibitor induces a dramatic increase in amyloid-beta peptide levels Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface human neprilysin-2-beta is either localized to the extracellular surface or secreted Homo sapiens 9986
-
extracellular due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta) Mus musculus
-
-
extracellular human neprilysin-2-beta is either localized to the extracellular surface or secreted Homo sapiens
-
-
membrane due to alternative splicing, murine NEP2 can exist in a membrane-bound form (mNEP2-alpha) or a secreted form (mNEP2-beta) Mus musculus 16020
-
additional information alternative splicing acts on the human form of neprilysin-2 creating several isoforms. Isoform hNEP2-gamma does not show secreted amyloid beta peptide-degrading activity or activity at the cell surface Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gonadotropin-releasing hormone + H2O Homo sapiens
-
?
-
?
additional information Mus musculus in vivo in cells membrane-bound isoforms mNEP2-alpha and mNEP2-beta have similar activity against amyloid beta peptide Ab40 and Ab42 compared to neprilysin, EC 3.4.24.11 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q495T6
-
-
Mus musculus Q9JLI3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood peripheral Homo sapiens
-
brain while NEP2 is expressed at variable levels in most brain regions, it is most highly expressed in the brain stem, hypothalamus and pituitary Mus musculus
-
brain while NEP2 is expressed at variable levels in most brain regions. Levels of neprilysin-2 mRNA in those with Alzheimer's disease are not different from non-impaired controls Homo sapiens
-
brain stem high enzyme level Mus musculus
-
hypothalamus high enzyme level Mus musculus
-
pituitary gland high enzyme level Mus musculus
-
testis
-
Mus musculus
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gonadotropin-releasing hormone + H2O
-
Homo sapiens ?
-
?
additional information in vivo in cells membrane-bound isoforms mNEP2-alpha and mNEP2-beta have similar activity against amyloid beta peptide Ab40 and Ab42 compared to neprilysin, EC 3.4.24.11 Mus musculus ?
-
?
additional information human neprilysin-2 has a more restricted substrate specificity compared to human neprilysin, EC 3.4.24.11, with less activity against several vasoactive peptides Homo sapiens ?
-
?
additional information in vitro membrane-bound isoform mNEP2-alpha has slower and weaker amyloid beta peptide Ab40 degrading properties when compared to neprilysin, EC 3.4.24.11, and shows little to no effect on amyloid beta peptide Ab42. Membrane-bound isozymes mNEP2-beta and gamma have nearly undetectable activity against amyloid beta peptide Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
membrane-bound metalloendopeptidase-like enzyme 1
-
Homo sapiens
membrane-bound metalloendopeptidase-like enzyme 2
-
Homo sapiens
MMEL1
-
Homo sapiens
MMEL2
-
Homo sapiens
NEP-like endopeptidase
-
Mus musculus
NEP-like endopeptidase
-
Homo sapiens
NEP2
-
Mus musculus
NEP2
-
Homo sapiens
NEPLP
-
Mus musculus
neprilysin-2
-
Mus musculus
neprilysin-2
-
Homo sapiens
neprilysin-like protein
-
Mus musculus
Nl1
-
Mus musculus
SEP
-
Mus musculus
soluble-secreted endopeptidase
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens the altered enzyme expression has a sexually dimorphic change, with mild-cognitive impaired males having significantly elevated NEP2 mRNA levels compared to non-impaired males in the mid-temporal and mid-frontal gyri additional information

General Information

General Information Comment Organism
evolution neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin Mus musculus
evolution neprilysin-2 is also a zinc metalloendopeptidase belonging to the same M13 family as neprilysin Homo sapiens
malfunction NEP2 knockout mice show reduced sperm function Mus musculus
malfunction reduced enzyme activity in association with mild-cognitive impaired subjects and Alzheimer's disease subjects regardless of sex Homo sapiens
metabolism neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain Mus musculus
metabolism neprilysin-2 (NEP2), a NEP-like endopeptidase, cooperates with neprilysin (NEP, EC 3.4.24.11) to control amyloid-beta peptide levels in the brain Homo sapiens
additional information enzyme splice variants and their involvement in amloid beta peptide cleavage, overview Mus musculus
additional information enzyme splice variants and their involvement in amyloid beta peptide cleavage, overview Homo sapiens
physiological function NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. Neprilysin-2 has importance in amyloid peptide regulation Mus musculus
physiological function NEP-like proteases, e.g. neprilysin-2, are important because of their potential involvement in the spike in amyloid beta peptide levels posttreatment with NEP inhibitors. The enzyme might play a role in the metabolism of neuropeptides of the hypothalamo-pituitary axis Homo sapiens