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Literature summary for 3.4.24.B12 extracted from

  • Sogame, S.; Suenaga, Y.; Atobe, M.; Kawanishi, M.; Tanaka, E.; Miyoshi, S.
    Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping (2014), Eur. J. Med. Chem., 71, 250-258.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-((1H-benzo[d]imidazol-2-yl)methylene)-5-propylthiazolidin-4-one potent small-molecule ADAMTS-5 inhibitor with good permeability Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UNA0
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
pH 7.5, 37°C Homo sapiens (E)-2-((1H-benzo[d]imidazol-2-yl)methylene)-5-propylthiazolidin-4-one
0.021
-
pH 7.5, 37°C Homo sapiens (E)-2-((1H-benzo[d]imidazol-2-yl)methylene)-5-propylthiazolidin-4-one