Literature summary for 3.4.24.B12 extracted from

Longpre, J.; McCulloch, D.; Koo, B.; Alexander, J.; Apte, S.; Leduc, R.
Characterization of proADAMTS5 processing by proprotein convertases (2009), Int. J. Biochem. Cell Biol., 41, 1116-1126.

Search for more literature for 3.4.24.B12

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	synthesized as a zymogen, proADAMTS5. The propeptide excision mechanism is a major regulatory step. proADAMTS5 is processed by proprotein convertases, specifically furin and PC7, but not PC6B. proADAMTS5 processing occurs after Arg261. Cleaved ADAMTS5 propeptide and mature ADAMTS5 are found exclusively in the conditioned medium. Extracellular ADAMTS5 processing is supported by activation of proADAMTS5 added exogenously to HEK-293 cells stably expressing furin	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ADAMTS5	-	Homo sapiens
aggrecanase-2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	key metalloprotease mediating cartilage destruction in arthritis	Homo sapiens

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Release 2023.1 (January 2023)