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Literature summary for 3.4.24.B12 extracted from
- Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5 (2008), Arthritis Rheum., 58, 1664-1673.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1alpha | increase of ADAMTS-5 in wild-type mice | Mus musculus | |
| retinoic acid | - |
Mus musculus |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | no enzyme activity in TS-5 deficient mice | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9R001 | no enzyme activity in TS-5 deficient mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | - |
Mus musculus | - |
| femur | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | 40 microg | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-5 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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