BRENDA - Enzyme Database
show all sequences of 3.4.24.B12

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

McCulloch, D.R.; Goff, C.L.; Bhatt, S.; Dixon, L.J.; Sandy, J.D.; Apte, S.S.; Gene Expr. Patterns 9, 314-323 (2009)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
versican + H2O
Mus musculus
expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
Q9R001
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
arterial smooth muscle cell
constitutive Adamts5 expression in adult tissue
Mus musculus
-
dorsal root ganglion
constitutive Adamts5 expression in adult tissue
Mus musculus
-
embryo
embryonic expression is scarce prior to 11.5 days of gestation (E11.5) and noted only in the floor plate of the developing brain at E9.5. After E11.5 there is continued expression in brain, especially in the choroid plexus, peripheral nerves, dorsal root ganglia, cranial nerve ganglia, spinal and cranial nerves, and neural plexuses of the gut. In addition to nerves, developing limbs have Adamts5 expression in skeletal muscle (from E13.5), tendons (from E16.5), and inter-digital mesenchyme of the developing autopod (E13.515.5)
Mus musculus
-
glomerular mesangial cell
in the kidney, constitutive Adamts5 expression in adult tissue
Mus musculus
-
mesothelium
lining the peritoneal, pericardial and pleural cavities, constitutive Adamts5 expression in adult tissue
Mus musculus
-
Schwann cell
of the peripheral and autonomic nervous system, constitutive Adamts5 expression in adult tissue
Mus musculus
-
smooth muscle cell
in bronchi and pancreatic ducts, constitutive Adamts5 expression in adult tissue. Expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
versican + H2O
expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
692482
Mus musculus
?
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
ADAMTS5
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
versican + H2O
Mus musculus
expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
arterial smooth muscle cell
constitutive Adamts5 expression in adult tissue
Mus musculus
-
dorsal root ganglion
constitutive Adamts5 expression in adult tissue
Mus musculus
-
embryo
embryonic expression is scarce prior to 11.5 days of gestation (E11.5) and noted only in the floor plate of the developing brain at E9.5. After E11.5 there is continued expression in brain, especially in the choroid plexus, peripheral nerves, dorsal root ganglia, cranial nerve ganglia, spinal and cranial nerves, and neural plexuses of the gut. In addition to nerves, developing limbs have Adamts5 expression in skeletal muscle (from E13.5), tendons (from E16.5), and inter-digital mesenchyme of the developing autopod (E13.515.5)
Mus musculus
-
glomerular mesangial cell
in the kidney, constitutive Adamts5 expression in adult tissue
Mus musculus
-
mesothelium
lining the peritoneal, pericardial and pleural cavities, constitutive Adamts5 expression in adult tissue
Mus musculus
-
Schwann cell
of the peripheral and autonomic nervous system, constitutive Adamts5 expression in adult tissue
Mus musculus
-
smooth muscle cell
in bronchi and pancreatic ducts, constitutive Adamts5 expression in adult tissue. Expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
versican + H2O
expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate
692482
Mus musculus
?
-
-
-
?
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755570
Aydos
ADAMTS1 and ADAMTS5 metallopr ...
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65
29-38
2019
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1
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753919
Dancevic
The ADAMTS5 metzincin regulat ...
Danio rerio
Int. J. Mol. Sci.
19
E766
2018
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2
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755160
Bauters
Functional role of ADAMTS5 in ...
Mus musculus
PLoS ONE
13
e0190595
2018
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1
1
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752719
Apte
Anti-ADAMTS5 monoclonal antib ...
Mus musculus
Biochem. J.
473
e1-e4
2016
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1
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1
1
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755055
McMahon
ADAMTS5 is a critical regulat ...
Mus musculus
PLoS Biol.
14
e1002580
2016
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6
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2
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733783
Sogame
Discovery of a benzimidazole s ...
Homo sapiens
Eur. J. Med. Chem.
71
250-258
2014
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1
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1
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734452
Durham
Identification of potent and s ...
Homo sapiens
J. Med. Chem.
57
10476-10485
2014
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734743
Wang
Matrilin-2 is proteolytically ...
Homo sapiens
Molecules
19
8472-8487
2014
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733436
Filou
Expression and distribution of ...
Homo sapiens
Biochimie
95
725-734
2013
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733484
Atobe
A series of thiazole derivativ ...
Homo sapiens
Bioorg. Med. Chem. Lett.
23
2106-2110
2013
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2
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733058
Kumar
ADAMTS5 functions as an anti-a ...
Homo sapiens
Am. J. Pathol.
181
1056-1068
2012
-
1
1
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1
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1
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733229
Ariyoshi
Mechanisms involved in enhance ...
Bos taurus
Arthritis Rheumatol.
64
187-197
2012
-
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1
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1
1
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734180
Didangelos
Novel role of ADAMTS-5 protein ...
Mus musculus
J. Biol. Chem.
287
19341-19345
2012
-
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3
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1
1
1
1
-
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734700
Filomia
-
Computational insights into AD ...
Homo sapiens
Mol. Inform.
31
421-430
2012
-
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1
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3
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3
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719385
Durigova
Involvement of ADAMTS5 and hya ...
Homo sapiens
Eur. Cell Mater.
21
31-45
2011
-
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2
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719966
Hattori
Pericellular versican regulate ...
Mus musculus
J. Biol. Chem.
286
34298-34310
2011
-
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2
2
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720093
Verma
ADAMTS-4 and ADAMTS-5: key enz ...
Homo sapiens
J. Cell. Biochem.
112
3507-3514
2011
1
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4
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2
2
1
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720363
Durigova
MMPs are less efficient than A ...
Homo sapiens
Matrix Biol.
30
145-153
2011
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720364
Groma
Matrilin-4 is processed by ADA ...
Mus musculus
Matrix Biol.
30
275-280
2011
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1
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720993
Shieh
Structure analysis reveals the ...
Homo sapiens
Protein Sci.
20
735-744
2011
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707442
Willems
Thiol isomerases negatively re ...
Homo sapiens
Biochem. J.
428
439-450
2010
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1
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1
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707445
Lim
Reactive-site mutants of N-TIM ...
Homo sapiens
Biochem. J.
431
113-122
2010
-
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1
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1
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708129
Cappelli
Design, synthesis, and prelimi ...
Homo sapiens
ChemMedChem
5
739-748
2010
-
-
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7
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1
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1
-
2
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-
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6
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6
7
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709662
Steinmeyer
In vitro inhibition of aggreca ...
Homo sapiens
J. Orthop. Res.
28
828-833
2010
-
-
-
-
-
-
3
-
-
-
-
-
-
1
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-
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-
-
-
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1
-
1
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3
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-
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-
3
3
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709707
Tsuzaka
ADAMTS5 is a biomarker for pre ...
Homo sapiens
J. Rheumatol.
37
1454-1460
2010
-
1
-
-
-
-
-
-
-
-
-
-
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2
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-
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710191
Malfait
ADAMTS-5 deficient mice do not ...
Mus musculus
Osteoarthr. Cartil.
18
572-580
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
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4
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1
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-
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-
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
691315
Shiozaki
Novel N-substituted 2-phenyl-1 ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
1575-1580
2009
-
-
-
-
-
-
28
-
-
-
-
-
-
1
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-
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2
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26
-
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26
28
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692482
McCulloch
Adamts5, the gene encoding a p ...
Mus musculus
Gene Expr. Patterns
9
314-323
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
7
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
1
-
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-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695958
Pockert
Modified expression of the ADA ...
Homo sapiens
Arthritis Rheum.
60
482-491
2009
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
696436
Miwa
Conserved sequence in the aggr ...
Homo sapiens
Biochim. Biophys. Acta
1790
161-172
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
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-
-
-
-
-
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2
-
1
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-
-
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-
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-
1
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696674
Hopper
Synthesis and biological evalu ...
Mus musculus
Bioorg. Med. Chem. Lett.
19
2487-2491
2009
-
1
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
-
1
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-
-
-
-
3
4
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698148
Demircan
Increased mRNA expression of A ...
Homo sapiens
Head Neck
10
793-801
2009
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707277
Lee
Co-culture of mechanically inj ...
Bos taurus
Arch. Biochem. Biophys.
489
118-126
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
707311
Seki
Effect of small interference R ...
Oryctolagus cuniculus
Arthritis Res. Ther.
11
R166
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707317
Chia
Fibroblast growth factor 2 is ...
Mus musculus
Arthritis Rheum.
60
2019-2027
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
707686
Shiozaki
Synthesis and SAR of 2-phenyl- ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
6213-6217
2009
-
-
-
-
-
-
20
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
-
-
-
15
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708082
Cudic
Analysis of flavonoid-based ph ...
Sus scrofa
Chem. Biol. Drug Des.
74
473-482
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
708744
Longpre
Characterization of proADAMTS5 ...
Homo sapiens
Int. J. Biochem. Cell Biol.
41
1116-1126
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
709044
Tortorella
Structural and inhibition anal ...
Homo sapiens
J. Biol. Chem.
284
24185-24191
2009
-
1
1
1
-
-
4
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
2
1
-
-
-
1
-
-
-
-
-
3
-
1
1
-
1
-
-
3
4
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
709790
Troeberg
The C-terminal domains of ADAM ...
Homo sapiens
Matrix Biol.
28
463-469
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
1
-
-
-
10
-
-
-
-
-
-
-
-
-
-
2
10
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
710041
Echtermeyer
Syndecan-4 regulates ADAMTS-5 ...
Homo sapiens
Nat. Med.
15
1072-1076
2009
1
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710190
Botter
ADAMTS5-/- mice have less subc ...
Mus musculus
Osteoarthr. Cartil.
17
636-645
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
677997
Sharghi-Namini
The first but not the second t ...
Homo sapiens
Biochem. Biophys. Res. Commun.
371
215-219
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679302
Bondeson
The regulation of the ADAMTS4 ...
Homo sapiens, Mus musculus
Clin. Exp. Rheumatol.
26
139-145
2008
2
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
4
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679600
Fosang
ADAMTS-5: the story so far ...
Bos taurus, Homo sapiens, Mus musculus
Eur. Cell Mater.
15
11-26
2008
7
-
2
-
-
-
9
-
1
-
-
-
-
6
-
-
-
-
-
9
-
-
4
-
9
-
-
-
-
-
-
-
-
-
-
-
7
-
2
-
-
-
-
-
9
-
-
1
-
-
-
-
-
-
-
-
9
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680903
Shieh
High resolution crystal struct ...
Homo sapiens
J. Biol. Chem.
283
1501-1507
2008
-
-
1
1
-
-
2
-
-
-
-
-
-
1
-
-
1
-
1
1
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
1
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680923
Fushimi
Functional differences of the ...
Homo sapiens
J. Biol. Chem.
283
6706-6716
2008
-
-
1
-
-
-
1
-
-
-
2
-
-
3
-
-
1
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682743
Mosyak
Crystal structures of the two ...
Homo sapiens
Protein Sci.
17
16-21
2008
-
-
1
1
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691313
Gilbert
N-((8-hydroxy-5-substituted-qu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
6454-6457
2008
-
-
-
-
-
-
56
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
56
-
-
-
-
-
-
-
56
56
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695404
Wang
Effects of RNAi-mediated inhib ...
Rattus norvegicus
Acta Pharmacol. Sin.
29
1215-1226
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695954
Rogerson
Evidence of a novel aggrecan-d ...
Mus musculus
Arthritis Rheum.
58
1664-1673
2008
2
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697804
Hamel
Multimodal signaling by the AD ...
Homo sapiens
Exp. Neurol.
210
428-440
2008
-
1
1
-
-
-
-
-
2
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
697847
Troeberg
Calcium pentosan polysulfate i ...
Homo sapiens
FASEB J.
22
3515-3524
2008
-
-
1
-
-
-
1
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-
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-
2
-
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-
-
-
-
-
-
-
-
-
-
-
697932
Takizawa
Calcium pentosan polysulfate d ...
Homo sapiens
FEBS Lett.
582
2945-2949
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
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1
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
677881
Song
Aggrecan degradation in human ...
Homo sapiens
Arthritis Rheum.
56
575-585
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678644
Bursavich
Synthesis and evaluation of ar ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
1185-1188
2007
-
-
-
-
-
-
35
-
-
-
-
-
-
2
-
-
-
-
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-
1
-
3
-
-
-
-
-
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-
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-
-
36
-
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-
36
35
-
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-
1
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
678645
Gilbert
5-((1H-pyrazol-4-yl)methylene) ...
Homo sapiens
Bioorg. Med. Chem. Lett.
17
1189-1192
2007
-
-
-
-
-
-
27
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
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-
-
19
-
-
-
-
-
-
-
19
27
-
-
-
-
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-
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680781
Gendron
Proteolytic activities of huma ...
Homo sapiens
J. Biol. Chem.
282
18294-18306
2007
1
-
1
-
-
-
3
-
-
1
-
-
-
2
-
-
1
-
-
2
-
-
8
-
3
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
-
2
-
-
8
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
680863
Ilic
Distinguishing aggrecan loss f ...
Mus musculus
J. Biol. Chem.
282
37420-37428
2007
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
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1
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1
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-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667827
Zeng
Glycosaminoglycan-binding prop ...
Homo sapiens
Biochim. Biophys. Acta
1760
517-524
2006
-
-
1
-
1
-
-
-
-
-
4
-
-
2
-
-
1
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667106
Nakada
Human glioblastomas overexpres ...
Homo sapiens
Acta Neuropathol.
110
239-246
2005
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668121
Miguel
Metalloproteinase ADAMTS-1 but ...
Homo sapiens
Brain Res. Mol. Brain Res.
133
1-5
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
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-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668982
Held-Feindt
Matrix-degrading proteases ADA ...
Homo sapiens
Int. J. Cancer
118
55-61
2005
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
1
1
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670373
Stanton
ADAMTS5 is the major aggrecana ...
Mus musculus
Nature
434
648-652
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669218
Tortorella
Alpha2-macroglobulin is a nove ...
Homo sapiens
J. Biol. Chem.
279
17554-17561
2004
-
-
1
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
395498
Boeckmann
The SWISS-PROT protein knowled ...
Bos taurus, Homo sapiens, Mus musculus
Nucleic Acids Res.
31
365-370
2003
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
3
-
21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651153
Vankemmelbeke
Selective inhibition of ADAMTS ...
Homo sapiens
Eur. J. Biochem.
270
2394-2403
2003
-
-
1
-
-
-
1
-
1
1
1
1
-
1
-
1
1
1
-
-
1
-
3
1
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
1
-
-
1
1
-
-
1
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
652268
Malfait
Inhibition of ADAM-TS4 and ADA ...
Homo sapiens
J. Biol. Chem.
277
22201-22208
2002
-
1
-
-
-
-
2
-
-
-
1
2
-
2
-
1
-
-
-
1
-
-
3
2
3
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
1
2
-
-
1
-
-
1
-
-
3
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
651091
Vankemmelbeke
Expression and activity of ADA ...
Bos taurus, Homo sapiens
Eur. J. Biochem.
268
1259-1268
2001
-
-
1
-
-
-
2
-
2
-
1
4
-
4
-
2
1
-
-
4
-
-
8
1
6
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
1
4
-
-
2
1
-
4
-
-
8
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
651525
Tang
ADAMTS: a novel family of extr ...
Bos taurus
Int. J. Biochem. Cell Biol.
33
33-44
2001
-
-
1
-
-
-
-
-
1
-
-
2
-
4
-
-
1
-
-
2
-
-
3
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652102
Kashiwagi
TIMP-3 is a potent inhibitor o ...
Homo sapiens
J. Biol. Chem.
276
12501-12504
2001
-
-
1
-
-
-
1
-
-
1
-
2
-
2
-
-
-
-
-
-
-
-
3
-
3
1
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-