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Literature summary for 3.4.24.B12 extracted from

  • McCulloch, D.R.; Goff, C.L.; Bhatt, S.; Dixon, L.J.; Sandy, J.D.; Apte, S.S.
    Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues (2009), Gene Expr. Patterns, 9, 314-323.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
versican + H2O Mus musculus expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate ?
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9R001
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Source Tissue

Source Tissue Comment Organism Textmining
arterial smooth muscle cell constitutive Adamts5 expression in adult tissue Mus musculus
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dorsal root ganglion constitutive Adamts5 expression in adult tissue Mus musculus
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embryo embryonic expression is scarce prior to 11.5 days of gestation (E11.5) and noted only in the floor plate of the developing brain at E9.5. After E11.5 there is continued expression in brain, especially in the choroid plexus, peripheral nerves, dorsal root ganglia, cranial nerve ganglia, spinal and cranial nerves, and neural plexuses of the gut. In addition to nerves, developing limbs have Adamts5 expression in skeletal muscle (from E13.5), tendons (from E16.5), and inter-digital mesenchyme of the developing autopod (E13.5–15.5) Mus musculus
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glomerular mesangial cell in the kidney, constitutive Adamts5 expression in adult tissue Mus musculus
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mesothelium lining the peritoneal, pericardial and pleural cavities, constitutive Adamts5 expression in adult tissue Mus musculus
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Schwann cell of the peripheral and autonomic nervous system, constitutive Adamts5 expression in adult tissue Mus musculus
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smooth muscle cell in bronchi and pancreatic ducts, constitutive Adamts5 expression in adult tissue. Expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
versican + H2O expression of Adamts5 during neuromuscular development and in smooth muscle cells coincides with the broadly distributed proteoglycan versican, an ADAMTS5 substrate Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
ADAMTS5
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 Mus musculus