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Literature summary for 3.4.24.B12 extracted from
- The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review (2008), Clin. Exp. Rheumatol., 26, 139-145.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | ADAMTS5 expression is not stimulated by interleukin-1, tumor necrosis factor alpha, oncostatin M or transforming growth factor beta | Mus musculus | |
| additional information | ADAMTS5 expression is not stimulated by interleukin-1, tumor necrosis factor alpha, oncostatin M or transforming growth factor beta | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | therapeutic target in osteoarthritis | Mus musculus |
| medicine | therapeutic target in osteoarthritis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | - |
Mus musculus | - |
| cartilage | - |
Homo sapiens | - |
| chondrocyte | - |
Mus musculus | - |
| chondrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | cleavage at Glu373-Ala374 bond | Mus musculus | ? | - |
? |  |
| aggrecan + H2O | cleavage at Glu373-Ala374 bond | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS5 | - |
Mus musculus |
| ADAMTS5 | - |
Homo sapiens |
| aggrecanase-2 | - |
Mus musculus |
| aggrecanase-2 | - |
Homo sapiens |
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