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Literature summary for 3.4.24.B12 extracted from
- Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage (2002), J. Biol. Chem., 277, 22201-22208.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential target for treatment of osteoarthritis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aggrecanase inhibitor BB-16 | prevents aggrecan degradation in osteoarthritic cartilage | Homo sapiens |  |
| additional information | no inhibition by matrix metalloprotease inhibitor XS309 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
x * 70000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | Homo sapiens | cleavage site is Glu373-Ala374 | ? | - |
? | |
| proteins + H2O | Homo sapiens | - |
peptides | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | several glycosylation sites | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | osteoarthritic, protein and mRNA | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | cleavage site is Glu373-Ala374 | Homo sapiens | ? | - |
? | |
| aggrecan + H2O | cleavage site is Glu373-Ala374, other cleavage sites are Glu1545-Gly1546, Glu1819-Ala1820, and Glu1919-Leu1920 | Homo sapiens | ? | - |
? | |
| proteins + H2O | - |
Homo sapiens | peptides | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, SDS-PAGE | Homo sapiens |
| More | a 30 kDa C-terminal truncated form, epitope mapping | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM-TS5 | - |
Homo sapiens |
| aggrecanase-2 | - |
Homo sapiens |
| M12.225 | Merops-ID | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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