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Literature summary for 3.4.24.B12 extracted from

  • Kashiwagi, M.; Tortorella, M.; Nagase, H.; Brew, K.
    TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5) (2001), J. Biol. Chem., 276, 12501-12504.
    View publication on PubMed
Search for more literature for 3.4.24.B12

Cloned(Commentary)

Cloned (Comment) Organism
expression in Drosophila S2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP-3 recombinant human inhibitor protein from Escherichia coli, i.e. tissue inhibitor of metalloproteinases, strong inhibitor with regulatory function Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloproteinase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Homo sapiens degradation of cartilage matrix ?
-
 ?
proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O cleavage site is Glu373-Ala374 Homo sapiens ?
-
 ?
aggrecan + H2O degradation of cartilage matrix Homo sapiens ?
-
 ?
proteins + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
ADAM-TS5
-
 Homo sapiens
aggrecanase-2
-
 Homo sapiens
M12.225 Merops-ID Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000066
-
 TIMP-3 pH 7.5, 37°C Homo sapiens