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Literature summary for 3.4.24.B10 extracted from

  • Albrechtsen, R.; Wewer Albrechtsen, N.J.; Gnosa, S.; Schwarz, J.; Dyrskjot, L.; Kveiborg, M.
    Identification of ADAM12 as a novel basigin sheddase (2019), Int. J. Mol. Sci., 20, E1957 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MCF-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
batimastat
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
basigin + H2O Homo sapiens the enzyme binds basigin and cleaves it in the juxta membrane region, thereby releasing a soluble basigin fragment to the extracellular space soluble basigin fragment + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
 Homo sapiens
-
HEK-293VnR cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
basigin + H2O the enzyme binds basigin and cleaves it in the juxta membrane region, thereby releasing a soluble basigin fragment to the extracellular space Homo sapiens soluble basigin fragment + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease 12
-
 Homo sapiens
ADAM12
-
 Homo sapiens
basigin sheddase
-
 Homo sapiens