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Literature summary for 3.4.24.B10 extracted from

  • Kotzsch, A.; Skovgaard, T.; Buus, U.; Andersen, S.; Devkota, K.; Berthelsen, J.
    A substrate-optimized electrophoretic mobility shift assay for ADAM12 (2014), Anal. Biochem., 452, 34-42.
    View publication on PubMed
Search for more literature for 3.4.24.B10

Inhibitors

Inhibitors Comment Organism Structure
batimastat
-
 Homo sapiens
GM6001
-
 Homo sapiens
marimastat
-
 Homo sapiens
MMP inhibitor III
-
 Homo sapiens
MMP inhibitor V
-
 Homo sapiens
MMP-3 inhibitor VIII
-
 Homo sapiens
TAPI-0
-
 Homo sapiens
TAPI-1
-
 Homo sapiens
TAPI-2
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
-
-

Purification (Commentary)

Purification (Comment) Organism
anion exchange column chromatography and concanavalin A column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293-EBNA cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-Fam-EFPIYDFLPAKKK-NH2 + H2O
-
 Homo sapiens 5-Fam-EFPI + YDFLPAKKK-NH2
-
 ?
5-Fam-FFLAQA(homophenylalanine)RSK-NH2 + H2O best substrate Homo sapiens 5-Fam-FFLAQA + (homophenylalanine)RSK-NH2
-
 ?
5-Fam-HADLAQA(homophenylalanine)RSK-NH2 + H2O
-
 Homo sapiens 5-Fam-HADLAQA + (homophenylalanine)RSK-NH2
-
 ?
5-Fam-HALAQA(homophenylalanine)RSK-NH2 + H2O
-
 Homo sapiens 5-Fam-HALAQA + (homophenylalanine)RSK-NH2
-
 ?
5-Fam-LAQA(homophenylalanine)RSK-NH2 + H2O
-
 Homo sapiens 5-Fam-LAQA + (homophenylalanine)RSK-NH2
-
 ?
5-Fam-SAVSRLRAYLLPA-NH2 + H2O
-
 Homo sapiens 5-Fam-SAVSRLR + AYLLPA-NH2
-
 ?
Dabcyl-LAQA(homophenylalanine)RSK(5-FAM)-NH2 + H2O
-
 Homo sapiens Dabcyl-LAQA + (homophenylalanine)RSK(5-FAM)-NH2
-
 ?
insulin-like growth factor binding protein-3 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM12
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000025
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens batimastat
0.000028
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens batimastat
0.00012
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP inhibitor V
0.00018
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP inhibitor V
0.00035
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-0
0.0004
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-0
0.00043
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens marimastat
0.0006
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP inhibitor III
0.00067
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens marimastat
0.001
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-1
0.0011
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP inhibitor III
0.0011
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens GM6001
0.0014
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-2
0.0014
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-1
0.0015
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP-3 inhibitor VIII
0.0018
-
 with 5-Fam-HALAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens TAPI-2
0.0021
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens GM6001
0.0028
-
 with 5-Fam-FFLAQA(homophenylalanine)RSK-NH2 as substrate, at pH 8.0 and 22°C Homo sapiens MMP-3 inhibitor VIII