Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B10 extracted from

  • Roy, R.; Rodig, S.; Bielenberg, D.; Zurakowski, D.; Moses, M.A.
    ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis (2011), J. Biol. Chem., 286, 20758-20768.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ADAM12 represents a potential therapeutic target in breast cancer Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000, truncated form, SDS-PAGE Homo sapiens
90000
-
x * 90000, active enzyme, SDS-PAGE Homo sapiens
120000
-
x * 120000, latent form, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O Homo sapiens
-
?
-
?
insulin-like growth factor binding protein-5 + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
Hs-578T cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-3 + H2O
-
Homo sapiens ?
-
?
insulin-like growth factor binding protein-5 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 120000, latent form, SDS-PAGE Homo sapiens
? x * 68000, truncated form, SDS-PAGE Homo sapiens
? x * 90000, active enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAM12-L transmembrane isoform Homo sapiens
ADAM12-S secreted isoform Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ADAM12 mRNA expression is elevated 10-30fold in malignant breast tissue and metastatic lymph nodes up

General Information

General Information Comment Organism
physiological function ADAM12 transmembrane and secreted isoforms promote breast tumor growth. The tumor-promoting activity of ADAM12-S is a function of its proteolytic activity. Only the secreted isoform enhances the ability of tumor cells to migrate and invade in vitro and results in a higher incidence of local and distant metastasis in vivo Homo sapiens