Application | Comment | Organism |
---|---|---|
medicine | ADAM12 represents a potential therapeutic target in breast cancer | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
x * 68000, truncated form, SDS-PAGE | Homo sapiens |
90000 | - |
x * 90000, active enzyme, SDS-PAGE | Homo sapiens |
120000 | - |
x * 120000, latent form, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin-like growth factor binding protein-3 + H2O | Homo sapiens | - |
? | - |
? | |
insulin-like growth factor binding protein-5 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Hs-578T cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin-like growth factor binding protein-3 + H2O | - |
Homo sapiens | ? | - |
? | |
insulin-like growth factor binding protein-5 + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 120000, latent form, SDS-PAGE | Homo sapiens |
? | x * 68000, truncated form, SDS-PAGE | Homo sapiens |
? | x * 90000, active enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ADAM12-L | transmembrane isoform | Homo sapiens |
ADAM12-S | secreted isoform | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ADAM12 mRNA expression is elevated 10-30fold in malignant breast tissue and metastatic lymph nodes | up |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAM12 transmembrane and secreted isoforms promote breast tumor growth. The tumor-promoting activity of ADAM12-S is a function of its proteolytic activity. Only the secreted isoform enhances the ability of tumor cells to migrate and invade in vitro and results in a higher incidence of local and distant metastasis in vivo | Homo sapiens |