Cloned (Comment) | Organism |
---|---|
expression of the enzymes cytoplasmic tail including or missing the alpha-actinin-2-binding site, tagged with a myristolation motif in C2C12 myoblast cells, in vitro transcription and translation of the enzyme, expression of the enzymes cytoplasmic tail including or missing the alpha-actinin-2-binding site as GST-fusion proteins in Escherichia coli XL-1 Blue | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of deletion mutants comprising the cytoplasmic tail with or without the alpha-actinin-2-binding site | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion | ? | - |
? | |
protein + H2O | Mus musculus | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61824 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | yoblast cell line | Mus musculus | - |
myoblast | C2C12 cell line, low content, is required for myoblast fusion | Mus musculus | - |
skeletal muscle | highly up-regulated in newly formed muscle fibers, enzyme is a marker of skeletal muscle regeneration, strongly binds to alpha-actinin-2 at the enzymes cytoplasmic tail | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion | Mus musculus | ? | - |
? | |
protein + H2O | - |
Mus musculus | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase domain 12 | - |
Mus musculus |
ADAM 12 | - |
Mus musculus |
ADAM12 | - |
Mus musculus |
M12.212 | Merops-ID | Mus musculus |
meltrin alpha | - |
Mus musculus |