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Literature summary for 3.4.24.87 extracted from
- A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor (2017), J. Biol. Chem., 292, 5760-5769 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| von Willebrand factor | the enzyme is conformationally activated by von Willebrand factor which engages the TSP8-CUB2 domains, inducing the conformational change that disrupts the CUB1-spacer domain interaction and thereby activates the enzyme | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| 568K/F592Y/R660K/Y661F/Y665F | the mutant shows enhanced proteolytic activity compared to the wild type enzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| FRETS-von Willebrand factor 73 + H2O | - |
Homo sapiens | ? | - |
? | |
| von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease with thrombospondin motifs 13 | - |
Homo sapiens |
| ADAMTS13 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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