Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.87 extracted from

  • Wang, Y.; Chen, J.; Ling, M.; Lopez, J.A.; Chung, D.W.; Fu, X.
    Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation (2015), J. Biol. Chem., 290, 1422-1431.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.87

Application

Application Comment Organism
medicine exposure of ADAMTS13 to activated human neutrophils results in oxidation of residues Met249, Met331, and Met496 in important functional domains ofADAMTS13. ADAMTS13 treated with either neutrophil elastase or plasmin is inhibited to a lesser extent, especially in the presence of plasma. Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H2O2 treatment with 25 nM myeloperoxidase plus 50 microM H2O2 reduces ADAMTS13 activity by >85%. Residues Met249, Met331, and Met496 in important functional domains of ADAMTS13 are oxidized to methionine sulfoxide in an HOCl concentration-dependent manner Homo sapiens
additional information exposure of ADAMTS13 to activated human neutrophils results in oxidation of residues Met249, Met331, and Met496 in important functional domains of ADAMTS13. ADAMTS13 treated with either neutrophil elastase or plasmin is inhibited to a lesser extent, especially in the presence of plasma. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q76LX8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
VWFA2 peptide + H2O substrate based on a 78-amino acid sequence corresponding to the sequence Leu1591-Arg1668 of the von Willebrand factor A2 domain Homo sapiens ?
-
 ?