Literature summary for 3.4.24.87 extracted from

Bao, J.; Xiao, J.; Mao, Y.; Zheng, X.L.
Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner (2014), Arterioscler. Thromb. Vasc. Biol., 34, 397-407.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q76LX8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
physiological function	carboxyl-terminal fragments of ADAMTS13 directly inhibit platelet adhesion/aggregation on a collagen surface under arterial shear. The carboxyl-terminal fragment of ADAMTS13 is capable of inhibiting the formation and elongation of platelet-decorated ultra-large von Willebrand factor strings and the adhesion of platelets/leukocytes on endothelium in mesenteric venules after oxidative injury. The inhibitory activity on platelet aggregation and ultra-large von Willebrand factor string formation are dependent on the presence of their surface free thiols	Homo sapiens

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Release 2023.1 (January 2023)