Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ADAMTS13 contains eight thrombospondin type 1 repeats and binds to CD36, a transmembrane protein present on endothelial cells and platelets. CD36 also binds to thrombospondin-2 via three thrombospondin type 1 repeats in a manner competitive to ADAMTS13, overview | ? | - |
? | |
von Willebrand factor + H2O | Homo sapiens | ADAMTS13 cleaves ultra-large von Willebrand factor multimers | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | ADAMTS13 associates to the platelet surface via binding of membrane-integrated CD36 | Homo sapiens | - |
endothelial cell | ADAMTS13 associates to the cell surface via binding of membrane-integrated CD36 | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ADAMTS13 contains eight thrombospondin type 1 repeats and binds to CD36, a transmembrane protein present on endothelial cells and platelets. CD36 also binds to thrombospondin-2 via three thrombospondin type 1 repeats in a manner competitive to ADAMTS13, overview | Homo sapiens | ? | - |
? | |
von Willebrand factor + H2O | ADAMTS13 cleaves ultra-large von Willebrand factor multimers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | binding of ADAMTS13 to CD36 on cell surfaces might be involved in ADAMTS13 regulation and regulation of von Willebrand cleavage | Homo sapiens |
physiological function | ADAMTS13 plays a significant role in vascular biology and thrombotic thrombocytopenic purpura | Homo sapiens |