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Literature summary for 3.4.24.87 extracted from
- Decreased ADAMTS13 levels in patients after living donor liver transplantation (2009), Thromb. Res., 124, 541-545.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secrete enzyme | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | ADAMTS13 and von Willebrand factor contents, overview | Homo sapiens | - |
| hepatoma cell | ADAMTS13 and von Willebrand factor contents, overview | Homo sapiens | - |
| liver | secretes the enzyme, ADAMTS13 activity in hepatic carcinoma, liver cirrhosis due to viral infection, primary biliary cirrhosis, cholestasis, and biliary atresia, overview | Homo sapiens | - |
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS13 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | decreased ADAMTS13 levels in patients after living donor liver transplantation, overview | Homo sapiens |
| physiological function | an unusually large multimer of Von Willebrand factor and ADAMTS13 may play an important role in the onset of thrombotic microangiopathy during liver transplantation. A significant reduction of ADAMTS13 and an increase of von Willebrand factor are observed in the patients with thrombotic microangiopathy-like syndrome, overview | Homo sapiens |
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