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Literature summary for 3.4.24.87 extracted from
- Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition (2009), PLoS Pathog., 5, e1000349.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | infection with Plasmodium falciparum inhibits ADAMTS13. ADAMTS13 activity in normal plasma is reduced by approximately 60% after pooled normal plasma is incubated in a 3:1 mix with malarial plasma for 30 min | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain | von Willebrand factor fragments | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | - |
Homo sapiens | von Willebrand factor fragments | - |
? | |
| von Willebrand factor + H2O | cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain | Homo sapiens | von Willebrand factor fragments | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS13 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAMTS13 regulates normal plasma van Willebrand factor multimer composition and thereby activity, through cleavage at the Tyr1605-Met1606 bond within the van Willebrand factor A2 domain | Homo sapiens |
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Release 2023.1 (January 2023)
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