Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
150000 | - |
x * 150000, SDS-PAGE, x * 190000, non-reducing PAGE | Homo sapiens |
190000 | - |
x * 150000, SDS-PAGE, x * 190000, non-reducing PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-498 cell | a renal carcinoma cell line | Homo sapiens | - |
epithelial cell | primary renal cortical cell cultures, real-time PCR and immunohistochemic analysis, overview | Homo sapiens | - |
kidney | in the renal cortex | Homo sapiens | - |
additional information | wide tissue distribution of ADAMTS13 expression | Homo sapiens | - |
plasma | ADAMTS13 circulates in plasma | Homo sapiens | - |
renal tubule | in both proximal and distal in healthy persons and in patients with renal disorders, e.g. tubulopathy | Homo sapiens | - |
urine | only in urine from patients with renal disorder tubulopathy | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
von Willebrand factor + H2O | substrate is FRET-VWF73 | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 150000, SDS-PAGE, x * 190000, non-reducing PAGE | Homo sapiens |
More | ADAMTS13 protease consists of a signal peptide, a short propeptide, the metalloprotease domain, a disintegrin-like domain, a thrombospondin-1 repeat, a Cys-rich domain, a spacer domain, seven additional thrombospondin-1 repeats, and two CUB domains | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin-like and metalloprotease with thrombospondin type-1 motifs 13 | - |
Homo sapiens |
ADAMTS13 | - |
Homo sapiens |
von Willebrand factor cleaving protease | - |
Homo sapiens |
von Willebrand factor-cleaving protease | - |
Homo sapiens |
vWF-cleaving protease | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS13 might regulate, after release by tubuli, the homeostasis in the local microenvironment in renal tubular epithelial cells | Homo sapiens |