Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged ADAMTS13 in HEK-293 cells, co-expression with thrombospondin1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secreted enzyme | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays | ? | - |
? | |
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q76LX8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | in cerebral corpora amylacea, that occur in aging brains and in patients with neurodegenerative conditions | Homo sapiens | - |
blood platelet | synthesizes and secreted ADAMTS13 | Homo sapiens | - |
brain | - |
Homo sapiens | - |
corpus amylaceum | in astrocytes of aging brains and patients with neurodegenerative conditions. Corporae amylaceae include glycosylated material, ubiquitin, and an assortment of proteins derived from neuronal cytoplasm. Many of these proteins are not specifically localized to neurons or astrocytes, some components of corpora amylacea, such as complement proteins, are most abundantly expressed outside the central nervous system. Corporae amylaceae can result from a conglomeration of interacting proteins from degenerating neurons and from extravasated blood elements released after transient breakdown of the blood-brain barrier | Homo sapiens | - |
liver | synthesizes and secreted ADAMTS13 | Homo sapiens | - |
neuronal cell | thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays | Homo sapiens | - |
plasma | the enzyme circulates in the blood | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | thrombospondin1 and ADAMTS13 form complexes together in cells and in direct protein binding assays | Homo sapiens | ? | - |
? | |
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS13 regulates physiological von Willebrand factor size | Homo sapiens |