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Literature summary for 3.4.24.87 extracted from

  • Kato, R.; Shinohara, A.; Sato, J.
    ADAMTS13 deficiency, an important cause of thrombocytopenia during pregnancy (2009), Int. J. Obstet. Anesth., 18, 73-77.
    View publication on PubMed
Search for more literature for 3.4.24.87

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens specific cleavage of ultra-large von Willebrand factor multimers ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O specific cleavage of ultra-large von Willebrand factor multimers Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs 13
-
 Homo sapiens
ADAMTS13
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 Homo sapiens
von Willebrand factor-cleaving metalloprotease
-
 Homo sapiens
VWF-cleaving metalloprotease
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS13 is a metalloprotease that limits admission and persistence of unusually large VWF multimers in the circulation, where they form abnormally large thrombi in the microvasculature. Thrombotic thrombocytopenic purpura is caused by congenital ADAMTS13 deficiency, and ADAMTS13 deficiency is an important cause of thrombocytopenia during pregnancy. Thrombotic thrombocytopenic purpura is a rare but life-threatening disease characterized by microangiopathic hemolytic anemia and consumptive thrombocytopenia leading to disseminated microvascular thrombosis Homo sapiens