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Literature summary for 3.4.24.87 extracted from

  • Wu, T.; Lin, J.; Cruz, M.A.; Dong, J.F.; Zhu, C.
    Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13 (2010), Blood, 115, 370-378.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.87

Activating Compound

Activating Compound Comment Organism Structure
additional information cleavage of von Willebrand factor A2 requires the force-induced A2 unfolding Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten ADAMTS-13/A1A2A3 binding kinetics, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens force-induced von Willebrand factor A2 domain unfolding of the substrate facilitates cleavage, using single VWF A1A2A3 tridomain polypeptides, structural destabilization of A1A2A3 was induced by 5- to 80-pN forces ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?
von Willebrand factor + H2O force-induced von Willebrand factor A2 domain unfolding of the substrate facilitates cleavage, using single VWF A1A2A3 tridomain polypeptides, structural destabilization of A1A2A3 was induced by 5- to 80-pN forces Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-13 i.e. a disintegrin and metalloprotease with a thrombospondin type 1 motifs 13 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.15
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS-13 regulates hemostasis by cleaving the folded A2 domain of von Willebrand factor. The cleavage is regulated by forces as it occurs in flowing blood. Mechanical regulation of VWF cleavage by ADAMTS-13 at the level of single A1A2A3 tridomain, overview Homo sapiens