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Literature summary for 3.4.24.87 extracted from

  • Scully, M.
    Inhibitory anti-ADAMTS 13 antibodies: measurement and clinical application (2010), Blood Rev., 24, 11-16.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Rituximab a monoclonal anti-CD 20 antibody, Rituximab leads to a prompt reduction in IgG antibody levels, followed by an increase in ADAMTS 13 activity increases. However, in patients receiving Rituximab electively, normalisation of ADAMTS 13 enzyme activity may be delayed for up to 3 months Homo sapiens

Application

Application Comment Organism
diagnostics role of ADAMTS 13 assays in diagnosis and prognosis of thrombotic thrombocytopenic purpura, TTP, overview Homo sapiens
drug development inhibitory anti-ADAMTS 13 antibodies, measurement and clinical application, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitory anti-ADAMTS 13 antibodies, measurement and clinical application, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metalloprotease ADAMTS-13 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS 13
-
Homo sapiens
metalloprotease ADAMTS-13
-
Homo sapiens

General Information

General Information Comment Organism
physiological function ADAMTS-13 deficiency is the cause for thrombotic thrombocytopenic purpura is an acute life threatening disorder, characterised by thrombocytopenia, microangiopathic haemolytic anaemia and multi organ microvascular thrombi that results in variable clinical symptoms Homo sapiens