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Literature summary for 3.4.24.87 extracted from

  • Zanardelli, S.; Crawley, J.T.; Chion, C.K.; Lam, J.K.; Preston, R.J.; Lane, D.A.
    ADAMTS13 substrate recognition of von Willebrand factor A2 domain (2006), J. Biol. Chem., 281, 1555-1563.
    View publication on PubMed
Search for more literature for 3.4.24.87

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00161
-
 von Willebrand factor 115 recombinant enzyme, at 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens cleavage of Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sephadex 26/10 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O cleavage of Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens ?
-
 ?
von Willebrand factor + H2O important role for Asp1614 and surrounding charged residues in the binding and cleavage of the von Willebrand factor A2 domain Homo sapiens ?
-
 ?
von Willebrand factor 115 (1554-1668) + H2O A2 domain fragment Homo sapiens ?
-
 ?
von Willebrand factor 115-A3 (1554-1874) + H2O A2 domain fragment Homo sapiens ?
-
 ?
von Willebrand factor 76 (1593-1668) + H2O A2 domain fragment Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.14
-
 von Willebrand factor 115 recombinant enzyme, at 37°C Homo sapiens