Literature summary for 3.4.24.86 extracted from

Lorenzen, I.; Lokau, J.; Korpys, Y.; Oldefest, M.; Flynn, C.M.; Kuenzel, U.; Garbers, C.; Freeman, M.; Groetzinger, J.; Duesterhoeft, S.
Control of ADAM17 activity by regulation of its cellular localisation (2016), Sci. Rep., 6, 35067 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
thrombin receptor agonistic peptide-6	SFLLRN	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface	Homo sapiens	9986	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 80000, mature enzyme, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase 17	-	Homo sapiens
ADAM17	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	protein kinase C-activating phorbol ester PMA, often used as a strong inducer of the enzyme, causes not only proteolysis by the enzyme but also a rapid increase of the mature protease at the cell surface. This is followed by internalisation and subsequent degradation of the protease. Eventually, this leads to a substantial downregulation of mature enzyme	down

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Release 2023.1 (January 2023)