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Literature summary for 3.4.24.86 extracted from

  • Arai, J.; Goto, K.; Tanoue, Y.; Ito, S.; Muroyama, R.; Matsubara, Y.; Nakagawa, R.; Kaise, Y.; Lim, L.A.; Yoshida, H.; Kato, N.
    Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells (2018), Int. J. Cancer, 143, 2575-2583 .
    View publication on PubMed
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
lomofungin 15% residual activity at 0.0125 mM, 6% residual activity at 0.05 mM, 0.03% residual activity at 0.1 mM Homo sapiens
TMI-1 complete inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
intercellular adhesion molecule 1 + H2O Homo sapiens
-
 soluble intercellular adhesion molecule 1 + ?
-
 ?
MHC class I polypeptide-related sequence A + H2O Homo sapiens
-
 soluble MHC class I polypeptide-related sequence A + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatocellular carcinoma cell
-
 Homo sapiens
-
PLC-PRF-5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
intercellular adhesion molecule 1 + H2O
-
 Homo sapiens soluble intercellular adhesion molecule 1 + ?
-
 ?
MHC class I polypeptide-related sequence A + H2O
-
 Homo sapiens soluble MHC class I polypeptide-related sequence A + ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Homo sapiens