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Literature summary for 3.4.24.86 extracted from

  • Duesterhoeft, S.; Michalek, M.; Kordowski, F.; Oldefest, M.; Sommer, A.; Roeseler, J.; Reiss, K.; Groetzinger, J.; Lorenzen, I.
    Extracellular juxtamembrane segment of ADAM17 interacts with membranes and is essential for its shedding activity (2015), Biochemistry, 54, 5791-5801 .
    View publication on PubMed
Search for more literature for 3.4.24.86

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MEF cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D647Q/E650Q/D654Q the mutant shows no significant change in activity compared to the wild type enzyme Homo sapiens
F652E/F655E the mutant is completely inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
interleukin-1 receptor II + H2O Homo sapiens
-
 ?
-
 ?
interleukin-6 receptor + H2O Homo sapiens
-
 ?
-
 ?
transforming growth factor alpha + H2O Homo sapiens
-
 ?
-
 ?
tumor necrosis factor alpha + H2O Homo sapiens
-
 ?
-
 ?
tumor necrosis factor alpha receptor I + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin-1 receptor II + H2O
-
 Homo sapiens ?
-
 ?
interleukin-6 receptor + H2O
-
 Homo sapiens ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
tumor necrosis factor alpha + H2O
-
 Homo sapiens ?
-
 ?
tumor necrosis factor alpha receptor I + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 130000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease-17
-
 Homo sapiens
ADAM17
-
 Homo sapiens