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Literature summary for 3.4.24.86 extracted from

  • Raikwar, N.; Liu, K.; Thomas, C.
    N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain (2014), PLoS ONE, 9, e112794.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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Homo sapiens
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HUVEC cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cell surface VEGF receptor Flt + H2O
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Homo sapiens ? release of an N-terminal extracellular fragment which can antagonize the effects of vascular endothelial growth factor ?
cell surface VEGF receptor Flt + H2O
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Homo sapiens ? substrate can be cleaved to release an N-terminal extracellular fragment. Overexpression of ADAM10, EC 3.4.24.81, and ADAM17 increase cleavage while knockdown of ADAM10 and ADAM17 reduce N-terminal cleavage ?

General Information

General Information Comment Organism
physiological function overexpression of ADAM10 and ADAM17 increase cleavage of cell surface VEGF receptor Flt while knockdown of ADAM10 and ADAM17 reduce N-terminal cleavage suggesting that these metalloproteases are responsible for Flt1 cleavage Homo sapiens