Application | Comment | Organism |
---|---|---|
medicine | ADAM17 expression levels are correlated with the invasive ability of androgen-independent prostate cancer cell lines. ADAM17 is overexpressed in cells showing high invasion characteristics, activation of the EGFR-MEK-ERK pathway, up-regulation of MMP-2, MMP-9, and an increased TGF-alpha release into the supernatant. AG1478, PD98059 and antibody against TGF-alpha deactivating the EGFR-MEK-ERK signaling pathway, abolish up-regulation of MMP-2, MMP-9 and prevent cell invasion. Cells with knock-down of ADAM17 by siRNA exhibit low invasive ability, deactivated EGFR-MEK-ERK signaling pathway, reduced TGF-alpha release and down-regulation of MMP-2, MMP-9 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78536 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |