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Literature summary for 3.4.24.86 extracted from

  • Chalaris, A.; Adam, N.; Sina, C.; Rosenstiel, P.; Lehmann-Koch, J.; Schirmacher, P.; Hartmann, D.; Cichy, J.; Gavrilova, O.; Schreiber, S.; Jostock, T.; Matthews, V.; Haesler, R.; Becker, C.; Neurath, M.; Reiss, K.; Saftig, P.; Scheller, J.; Rose-John, S.
    Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice (2010), J. Exp. Med., 207, 1617-1624.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Application

Application Comment Organism
medicine ADAM17 is a potential drug target in tumor necrosis factor and/or epidermal growth factor receptor–dependent pathologies in inflammation and cancer Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epidermal growth factor receptor + H2O Mus musculus
-
 ?
-
 ?
L-selectin + H2O Mus musculus
-
 ?
-
 ?
proTNF-alpha + H2O Mus musculus
-
 soluble TNF-alpha + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epidermal growth factor receptor + H2O
-
 Mus musculus ?
-
 ?
L-selectin + H2O
-
 Mus musculus ?
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha + ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease 17
-
 Mus musculus
ADAM17
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ADAM17 is expressed in most tissues and is up-regulated during inflammation and cancer up

General Information

General Information Comment Organism
malfunction ADAM17-deficient mice are not viable. Mice with dramatically reduced ADAM17 levels show substantially increased susceptibility to inflammation in dextran sulfate sodium colitis and develop eye, heart, and skin defects Mus musculus
physiological function ADAM17 is needed for vital regenerative activities during the immune response. ADAM17 is not crucial for developmental Notch or Notch ligand function in vivo Mus musculus