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Literature summary for 3.4.24.86 extracted from

  • Chalaris, A.; Rose-John, S.
    Proteases. ADAM 17: Molecular switch between inflammation and regeneration (2011), BIOspektrum, 17, 506-509.
No PubMed abstract available
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of metalloproteinases-3 natural inhibitor of ADAM17 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-EGF receptor + H2O Mus musculus
-
 EGF receptor + ?
-
 ?
pro-interleukin-6 receptor + H2O Mus musculus
-
 interleukin-6 receptor + ?
-
 ?
pro-L-selectin + H2O Mus musculus
-
 L-selectin + ?
-
 ?
pro-Notch 1 + H2O Mus musculus
-
 Notch 1 + ?
-
 ?
pro-TNF-alpha + H2O Mus musculus
-
 soluble TNF-alpha + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-EGF receptor + H2O
-
 Mus musculus EGF receptor + ?
-
 ?
pro-interleukin-6 receptor + H2O
-
 Mus musculus interleukin-6 receptor + ?
-
 ?
pro-L-selectin + H2O
-
 Mus musculus L-selectin + ?
-
 ?
pro-Notch 1 + H2O
-
 Mus musculus Notch 1 + ?
-
 ?
pro-TNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha + ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ADAM17 expression is increased in chronically inflamed tissue up

General Information

General Information Comment Organism
malfunction inhibition of ADAM17 protects from lipopolysaccharide-induced sepsis Mus musculus
physiological function ADAM17 has pro-inflammatory activity, protects from osteoporosis and is necessary for the growth of lung cancer cells Mus musculus