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Literature summary for 3.4.24.86 extracted from

  • Vahdat, A.M.; Reiners, K.S.; Simhadri, V.L.; Eichenauer, D.A.; Boell, B.; Chalaris, A.; Simhadri, V.R.; Wiegmann, K.; Krell, H.W.; Rose-John, S.; Engert, A.; von Strandmann, E.P.; Hansen, H.P.
    TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species (2010), Leukemia, 24, 51-57.
    View publication on PubMed
Search for more literature for 3.4.24.86

Activating Compound

Activating Compound Comment Organism Structure
bortezomib stimulates ADAM17-catalyzed shedding of CD30, blocks bortezomib-stimulated sCD30 release from L540 cells with an IC50 of approximately 230 nM Homo sapiens

Application

Application Comment Organism
medicine inhibition of ADAM17 increases the cytotoxicity of bortezomib and MDX-060 against L-540 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ro32-7315 inhibitor specific for ADAM17, blocks shedding of CD30 antigen from cell membrane and a simultaneous release of soluble CD30 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
KARPAS-299 cell large cell anaplastic lymphoma cell line Homo sapiens
-
L-428 cell CD30-positive Hodgkin’s lymphoma cell line Homo sapiens
-
L-540 cell CD30-positive Hodgkin’s lymphoma cell line Homo sapiens
-
REH cell CD30-negative acute lymphoblastic leukemia cell line Homo sapiens
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RPMI-8226 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD30 + H2O shedding of CD30 upon inhibition of the proteasome is catalyzed by ADAM17 Homo sapiens ?
-
 ?