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Literature summary for 3.4.24.86 extracted from

  • Dusso, A.; Arcidiacono, M.V.; Yang, J.; Tokumoto, M.
    Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality (2010), J. Steroid Biochem. Mol. Biol., 121, 193-198.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine 1,25-dihydroxyvitamin D inhibition of TACE is a potential common mechanism underlying the efficacy of therapy with 1,25-dihydroxyvitamin D or its analogs to improve outcomes in chronic kidney disease. 1,25-dihydroxyvitamin D prevents/moderates not only the onset and progression of parathyroid TACE/TGFalpha-driven secondary hyperparathyroidism, but renal TACE/TGFalpha-driven fibrotic and inflammatory lesions to the renal parenchyma, and TACE/TNFalpha-driven systemic inflammation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,25-dihydroxyvitamin D 1,25-dihydroxyvitamin D inhibition of TACE is a potential common mechanism underlying the efficacy of therapy with 1,25-dihydroxyvitamin D or its analogs to improve outcomes in chronic kidney disease. 1,25-dihydroxyvitamin D prevents/moderates not only the onset and progression of parathyroid TACE/TGFalpha-driven secondary hyperparathyroidism, but renal TACE/TGFalpha-driven fibrotic and inflammatory lesions to the renal parenchyma, and TACE/TNFalpha-driven systemic inflammation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
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