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Literature summary for 3.4.24.86 extracted from

  • Boutet, P.; Agüera-Gonzalez, S.; Atkinson, S.; Pennington, C.; Edwards, D.; Murphy, G.; Reyburn, H.; Valés-Gómez, M.
    Cutting edge: The metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein (2009), J. Immunol., 182, 49-53.
    View publication on PubMed
Search for more literature for 3.4.24.86

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane detergent-resistant membrane microdomain, i.e. regions of the membrane enriched in cholesterol and sphingolipids Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MHC class I-related chain + H2O i.e. transmembrane protein expressed in pathological conditions, ligands for the activating receptor NKG2D found on cytotoxic lymphocytes. The recruitment of both enzyme and substrate to detergent-resistant membrane microdomains is crucial for efficient proteolysis Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function inhibition and knockdown of ADAM17/TACE blocks the shedding of MHC class I-related chain. The recruitment of both enzyme and substrate to detergent-resistant membrane microdomains is crucial for efficient proteolysis Homo sapiens