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Literature summary for 3.4.24.86 extracted from

  • Szalad, A.; Katakowski, M.; Zheng, X.; Jiang, F.; Chopp, M.
    Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia (2009), J. Exp. Clin. Cancer Res., 28, 129.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine transcription factor Sp1 binds to the ADAM17 promoter, and Sp1 regulates ADAM17 expression under hypoxia. Suppression of Sp1 decreases invasiveness and migration in U87 tumor cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-87MG cell
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens transcription factor Sp1 binds to the ADAM17 promoter, and Sp1 regulates ADAM17 expression under hypoxia. Suppression of Sp1 decreases invasiveness and migration in U87 tumor cells up